Blar i NILU Brage på forfatter "Doak, Shareen H."

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    • Common Considerations for Genotoxicity Assessment of Nanomaterials 

      Elespuru, Rosalie K.; Doak, Shareen H.; Collins, Andrew Richard; Dusinska, Maria; Pfuhler, Stefan; Manjanatha, Mugamane; Cardoso, Renato M.S.; Chen, Connie L. (Peer reviewed; Journal article, 2022)
      Genotoxicity testing is performed to determine potential hazard of a chemical or agent for direct or indirect DNA interaction. Testing may be a surrogate for assessment of heritable genetic risk or carcinogenic risk. Testing ...

    • Current status and future challenges of genotoxicity OECD Test Guidelines for nanomaterials: a workshop report 

      Doak, Shareen H.; Andreoli, Cristina; Burgum, Michael J.; Chaudhry, Qasim; Bleeker, Eric; Bossa, Cecilia; Domenech, Josefa; Drobne, Damjana; Fessard, Valérie; Jeliazkova, Nina; Longhin, Eleonora Marta; Rundén-Pran, Elise; Stepnik, Maciej; El Yamani, Naouale; Catalán, Julia; Dusinska, Maria (Peer reviewed; Journal article, 2023)
      Genotoxicity testing for nanomaterials remains challenging as standard testing approaches require some adaptation, and further development of nano-specific OECD Test Guidelines (TGs) and Guidance Documents (GDs) are needed. ...

    • The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials 

      El Yamani, Naouale; Rundén-Pran, Elise; Collins, Andrew Richard; Longhin, Eleonora Marta; Elje, Elisabeth; Hoet, Peter; Vrček, Ivana Vinković; Doak, Shareen H.; Fessard, Valérie; Dusinska, Maria (Peer reviewed; Journal article, 2022)
      The in vitro comet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs ...

    • Use of in vitro 3D tissue models in genotoxicity testing: Strategic fit, validation status and way forward. Report of the working group from the 7th International Workshop on Genotoxicity Testing (IWGT) 

      Pfuhler, Stefan; van Benthem, Jan; Curren, Rodger; Doak, Shareen H.; Dusinska, Maria; Hayashi, Makoto; Heflich, Robert H.; Kidd, Darren; Kirkland, David; Luan, Yang; Ouedraogo, Gladys; Reisinger, Kerstin; Sofuni, Toshio; van Acker, Frederique; Yang, Ying; Corvi, Raffaella (Peer reviewed; Journal article, 2020)
      Use of three-dimensional (3D) tissue equivalents in toxicology has been increasing over the last decade as novel preclinical test systems and as alternatives to animal testing. In the area of genetic toxicology, progress ...